Abstract :
Peptic ulcer bleeding is a major complication of peptic ulcer disease and carries significant morbidity and
mortality. Current evidence suggests that H. pylori and NSAIDs increased risk of peptic ulcer bleeding and these two factors seem to act independently. Patients with peptic ulcer bleeding should be tested for H. pylori infection, regardless of the use of NSAIDs. Eradication therapy with a proton pump based triple therapy should be given to all H. pylori-positive patients. After eradication, acid-suppressant therapy is advised to heal the ulcer. The success of eradication should be confirmed because of the risk of recurrence of peptic ulcer disease and bleeding complication.
Key words : Helicobacter pylori, peptic ulcer bleeding
[Thai J Gastroenterol 2004; 5(1): 24-28]
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file/Thai-Journal-of-gastroenterology-vol-5-no-1-4859321.pdf