Abstract :
Background:
Rapid urease test (RUT) is commonly used in diagnosis of Helicobacter pylori (H. pylori)
infection. Previous studies suggested that if there was low density of
longer time to become positive. Therefore, in patients with recent usage of proton pump inhibitors (PPIs) which
reduce the density of
H. pylori in the stomach, RUT neededH. pylori, the RUT may require longer reading time as well.
Objective:
used PPIs.
To compared the RUT (Pronto dry®) results at one and 24 hours in patients who recently
Material and Methods:
the corpus were obtained from 546 dyspeptic patients taking PPIs. Both antral and corpus specimens were used for
RUT (Pronto dry
The result of RUT was observed at one and 24 hours. The histopathologic examinations were used as the gold
standard.
Four gastric mucosal biopsy specimens, two from the antrum and two from®), Medical instruments Corporation, Solothurn, Switzerland) and histopathologic examinations.
Results:
pylori
There were 113 patients had negative results at one hour and positive results at 24 hours. Among these patients, 16
patients had positive histopathologic findings.
Of 546 dyspeptic patients, 95 patients (17.4%) had positive histopathologic findings for H.infection. Whereas 81 (14.8%) and 194 (35.5%) patients had positive RUT at one and 24 hours respectively.
Conclusion:
In PPIs- used patients, evaluation of RUT (Pronto dry®) at 24 hours may increase the chance to detect |
file/Thai-Journal-of-gastroenterology-vol-10-no-1-2287301.pdf