Abstract :
Background & Aims:
Gastric cancer is one of the most common malignancies worldwide. We performed to detect the correlation of various clinicopathological parameters with p53 expressions and serum anti p53 antibodies in Thai patients with gastric cancers.
Methods and Materials:
Thirty eight patients with histological proven gastric cancer were recruited at King Chulalongkorn Memorial Hospital from 2001 to 2005. The tissues were collected for immunohistochemical detection of p53 and sera were analyzed for p53 antibodies using ELISA technique. The clinicopathological data were collected.
Results:
Of 38 patients, there were 40.5% males and 59.9% females (mean age 63.48 ± 11.96 years). 6/8 (75.0%) of the positive p53 immunoreactivity patients had histological well to moderate differentiated adenocarcinoma, compared to 15/28 (53.6%) of those had histological poor differentiated adenocarcinoma or signet ring type. (p = 0.278). There were no relationships of p53 expression or serum anti p53 antibodies with clinicopathological data were collected including age, sex, symptom, presentation, history of cigarette smoking and alcohol drinking, lesion site, metastasis, treatment,
Conclusion:
These results suggest that the expression of p53 or the detection of p53 antibodies has no significant impact on the outcome of Thai patients with gastric cancer.
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file/Thai-Journal-of-gastroenterology-vol-10-no-2-3596200.pdf