Abstract :
Background: Colonic cleansing with sodium phosphate causes intravascular volume contraction in
some patients. This study tested the hypothesis that oral rehydration solution protects against intravascular volume
contraction during colonic cleansing with orally administered NaP.
Methods: Adult outpatients were randomized to ingest the regular clear fluid or an oral rehydration
solution (ORS) during pre-colonoscopy purgation by ingestion of aqueous sodium phosphate. Clinical hemodynamic
measurements and biochemical tests were obtained at baseline and after bowel preparation. Tolerability and
colonoscopy visualization were assessed with questionnaires.
Results: One hundred sixty patients completed the study. There were 80 patients receiving regular
clear fluid (control group) and 80 patients receiving ORS (treatment group). By comparison with control, the
treatment group resulted in significantly less intravascular volume contraction. The changes in orthostatic pulse (p
<0.045), BUN/Cr ratio (p <0.002), urine specific gravity (p <0.000) were significantly greater in control than
treatment group. The changes in biochemical parameters after purgation also suggested a greater degree of volume
contraction in control than treatment group. Tolerability of the preparations was similar in both groups (p = 0.809).
Conclusions: Oral rehydration solution protects against intravascular volume contraction during preparation
for colonoscopy by ingestion of sodium phosphate. This approach is well tolerated by patients. |
file/Thai-Journal-of-gastroenterology-vol-11-no-2-19408.pdf