Abstract :
Background: We evaluated the performance characteristics of computed tomographic (CT) colonography
for the detection of colorectal neoplasia in an average-risk screening population. In addition to an early detection
of cancer-precursor lesions, the treatment of early stage cancer can help reduce cancer related death rate from
advanced colorectal cancer.
Methods: A total of 43 asymptomatic adults (mean age, 64.88 years) underwent CT colonography
followed by conventional colonoscopy on the same day. Two-dimensional endoluminal display was employed for
the initial detection of polyps on CT colonography. As for total colonoscopy, the colonoscopist was not aware of
CT colonography findings. The sensitivity and the specificity of CT colonography were calculated based on the
conventional colonoscopic findings as the reference standard.
Results: The sensitivity of CT colonography for detection of adenomatous polyps was 84.2% for polyps
of all sizes, 66.67% for polyps 6 mm or larger in diameter, and 86.7% for polyps smaller than 6 mm diameter.
The specificity of CT colonography for detection of adenomatous polyps was 89.3% for polyps of all sizes. The
accuracy of CT colonography for detection all polyps was 87.2%, 66.67% for polyps 6 mm or larger in diameter,
and 76.47% for polyps smaller than 6 mm diameter. A large ulcerative mass lesion in one patient was malignant.
Conclusions: CT colonography with the use of a two-dimensional approach is an accurate screening
method for the detection of colorectal neoplasia in asymptomatic average-risk adults, and compares favorably with
conventional colonoscopy in terms of the detection of clinically relevant lesions. |
file/Thai-Journal-of-gastroenterology-vol-13-no-2-320413.pdf