Thai Journal of Gastroenterology

Article :
High-Versus Low Dose Pantoprazole for Optimal Inhibition of Gastric Acid in Patients with Peptic Ulcer Bleeding

Author :
Luangpairat W
Sutthivana C

Abstract :
Background: Proton-pump inhibitor (PPI) was used to treat patients with peptic ulcer bleeding. There was no standardized effective dosing regimen, so various doses of PPI were used to treatment for peptic ulcer bleeding. The aim of this study was to evaluate the efficacy of various doses of PPI on the intragastric pH in Thai patients Methods: A prospective randomized study was conducted in 60 patients with peptic ulcer bleeding. Patients were randomized into two groups to receive a high-dose intravenous PPI regimen (80 mg bolus followed by 8 mg/hr) or a low-dose intravenous PPI regimen (40 mg bolus twice a day). The primary endpoint was 24 hr intragastric pH. Secondary end points were the antisecretory effect on 24 hr intragastric pH levels in relation to H. pylori infection and the rebleeding rate within 7 days. Results: The mean 24 hr intragastric pH values did not differ significantly between low dose pantoprazole group and high-dose pantoprazole group and demonstrated the similar effect on acid inhibition regardless of the absence or presence of H. pylori. Conclusion: In patients with peptic ulcer bleeding, pantoprazole 40 mg bolus twice a day or high- dose pantoprazole regimen was not significantly different in 24 hr intragastric pH in Thai patients.

Keyword :
Proton-pump inhibitor, pantoprazole, peptic ulcer bleeding

PDF Download :
file/Thai-Journal-of-gastroenterology-vol-13-no-3-1814320.pdf