Abstract :
Background: Significance of liver steatosis (LS) in patients with chronic viral hepatitis B (CHB) was
less clear in terms of prevalence, factors in association, relation to HBV-related liver injury, and pathologic charac-
teristics. This study was aimed to explore these problems.
Results: A total of 60 patients with CHB, liver steatosis were present in 19 patients (31.7%). All viral
factors had shown no significant association with liver steatosis (p>0.05). Body mass index and fasting HDL-
cholesterol showed significant correlation with steatosis (p=0.007 for BMI and p=0.02 for fasting HDL-choles-
terol). Different histologic parameters according to METAVIR was not found among patients with and without
liver steatosis (p>0.05). Compared to patients without liver steatosis, patients with liver steatosis had more balloon-
ing hepatocytes (89% vs. 32%; p<0.0001), Mallory bodies (68.4% vs. 9.8%; p<0.0001), large lipogranuloma (31.6%
vs. 0%; p=0.001), and glycogenated nuclei (26.3% vs. 4.9%; p=0.028). Mean NAS was also higher among patients
with liver steatosis (p<0.00001). Ballooning hepatocytes, degree of lobular inflammation, portal inflammation,
fibrosis according to Kleiner’s classification, and any Mallory bodies were found to be associated with significant
HBV-related liver disease (p<0.05). Limitations of these preliminary results were mainly due to its relatively small
sample size and inability to perform multivariate analysis. More patient enrollment is needed to finalize the results. |
file/Thai-Journal-of-gastroenterology-vol-14-no-1-2301479.pdf