Abstract :
Background and Aims: Helicobacter pylori infection and its associated diseases are an important
health issue, but the data in Thailand was limit. The purpose of this study is to evaluate the prevalence of H. pylori
infection in Thailand and investigate the association between the infection and demographic characteristics and
gastric diseases.
Methods: All consecutive patients undergoing upper endoscopy in the King Chulalongkorn Memorial
Hospital from 2008 to 2009 were reviewed for demographic data, endoscopic finding, and H. pylori infection
diagnoses by using rapid urease test.
Results: Among 3208 patients included, 1451 (45.2%) were male and 1757 (54.8%) are female with
mean age of 56.5 ± 15.3 years. There were 882 cases (27.5%) of peptic ulcers (consisting of GU 530 (16.5%), DU
226 (7.0%), and both GU and DU 126 (3.9%)), 898 cases (28.0%) of GERD, 229 cases (7.1%) of portal hypertension
and 25 cases (0.8%) of suspected gastric cancer. H. pylori infection was associated with male gender, younger
age, duodenal ulcer and both GU and DU (p = 0.001, 0.003, 0.006 and 0.014, respectively). Peptic ulcers are also
more commonly found in male and older age group (p <0.001). Gastroduodenitis patients tended to be female and
younger compared with their counterparts (p <0.001).
Conclusions: H. pylori infection was common in Thailand and a major health care problem, even
though the trend did seem to have been decreasing. The prevalence of peptic ulcer disease and H. pylori infection
are varied with age and genders.
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file/Thai-Journal-of-gastroenterology-vol-14-no-2-566337.pdf