Article :
Case Report: Fatal Acute-on-Chronic Liver Failure from Amiodarone Toxicity
Author :
Poovorawan K
Wisedopas N
Treeprasertsuk S
Komolmit P
Abstract :
Background: Drug induced liver injury is common problem in clinical practice. Amiodarone hepatotoxicity has various clinical presentations from asymptomatic elevation of aminotransferase to acute liver failure.
Objective: To investigate the clinicopathological characteristics of acute-on-chronic liver failure from amiodarone toxicity.
Material and Method: One case of amiodarone toxicity was reported in a review of literature. The clinical and histopathological features were described.
Results: We report a 62-year-old female patient with prolong administration of amiodarone. She developed clinical of acute-on-chronic liver failure. Liver pathology reported cholestatic hepatitis with extensive Mallory’s body with pericellular fibrosis. Amiodarone induce hepatotoxicity was diagnosed.
Conclusion: This report suggests that amiodarone toxicity should be considered as one possibly cause of acute-on-chronic liver failure.
Keyword :
Amiodarone, drug toxicity, acute-on-chronic liver failure, fatal, ascites.
file/Thai-Journal-of-gastroenterology-vol-15-no-2-3822464.pdf