Abstract :
Aims: To compare the efficacy of colon cleansing for colonoscopy between itopride hydrochloride plus
polyethylene glycol group and polyethylene glycol alone.
Methods: This was a randomized controlled trial comparing the efficacy of colon cleansing for
colonoscopy between itopride hydrochloride plus polyethylene glycol (PEG) and polyethylene glycol alone in
patients undergoing an elective colonoscopy at the Division of Gastroenterology, Department of Medicine, Faculty
of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, between January 2014 and December 2014.
Results: A total of 82 patients were enrolled, 41 (50%) in the itopride hydrochloride plus polyethylene
glycol group (combination group), and 41 (50%) in the polyethylene glycol alone group (PEG group). In the
combination group, 24 patients (58.5%) achieved an optimal bowel preparation (Ottawa scale ≤ 4) with an average
score of 3.9 ± 2.69. In the PEG group, 17 patients (41.5%) achieved optimal bowel preparation with an average
score of 4.83 ± 2.66. The difference was not statistically significant (p=0.12). The number of patients in the combination
group with total fluid score of 0 was statistically higher than that in the PEG group (41.5% vs. 19.5%, p =
0.03). In the combination group, 2 cases of abdominal discomfort (4.9%) and 2 cases of nausea and vomiting
(4.9%) were reported (p=0.24), whereas in the PEG group, 5 cases of abdominal discomfort (12.2 %) and 4 cases of
nausea and vomiting (9.8 %) were noted (p=0.24, 0.39). The difference was not statistically significant.
Conclusion: Colonic bowel preparation by adding itopride hydrochloride 50 mg to the split-regimen of
2-liter PEG increased the number of patients with minimal colonic fluid residue with statistical significance.
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file/Thai-Journal-of-gastroenterology-vol-16-no-3-1944367.pdf