Abstract :
Host genetic factor has been shown to be influential at least partly in determinating treatment responsiveness. For HCV infection, RANTES polymorphisms has been theoretically speculated and subsequently proven by few association studies to play a role in antiviral treatment response. We conducted a study to determine whether in Thai population, RANTES polymorphisms may also exert such effect. Using 40 HCV genotype 3 infected patients, we gathered demographic data and genotyped each individual at three separate RANTES SNPs. Results showed that one of the SNPs, IVS1 +306 T/C, was associated with treatment response variation. IVS1 +306 C allele was found to be statistically higher frequency in nonesponder group. This result, if replicable and confirmable, may lead to an integrated molecular testing prior to HCV antiviral treatment similar to those beginning to be used in HIV infection.
[Thai J Gastroenterol 2006; 7(2): 77-82] |
file/Thai-Journal-of-gastroenterology-vol-7-no-2-3762457.pdf